SOMETHING TO TICKLE YOU MANS TASTEBUDS...

[Stamina Man]

WHO KNOWS?I COULD EAT THIS 24-7 AND DIE OF CLOGGED ARTERIES AT 21

[ReZiW]

i dnt know. where can i cop? looks ayt

[Axiom]

looks disgusting sanwill try it 1 dayoi where's my heart clogger crew atdurty i see u san

[Stamina Man]

i dnt know. where can i cop? looks ayt

You just need to grill a feta based cheese, add some lemon on that, and eat. Don't think you can buy.

looks disgusting sanwill try it 1 dayoi where's my heart clogger crew atdurty i see u san

NAH ITS NOICE

[Ephren Taylor]

I hate anything with cheese except Pizza & Lasagne. Those items only get dealt with if its strictly Mozzarella business

[Guest David Braund]

IM HERE GEEran out of peanut butter so cnt do my heart attack sandwich now(what u now bout jus dippin ur finger in the jar n lickin it)doesnt look appealing doeso its jus grilled cheese with a lemon?

[SPEAK NO EVIL]

AtherosclerosisArteriosclerosis is a thickening and toughening of arterial walls (sclerosis – hardening)It takes 2 major forms- Focal calcification is the deposition of calcium salts following the gradual degenerationof smooth muscle in the tunica media. Typically, this process involves arteries of thelimbs and genital organs. It occurs as part of the aging process and may develop in assocwith atherosclerosis.- Atherosclerosis is the formation of lipid deposits in the tunica media associated withdamage to the endothelial lining.3 stages of development.Endothelial damageUptake of modified LDL, adhesion and infiltration of macrophagesSmooth muscle proliferation and formation of a fibrous capECs can respond to their environment. Endothelial dysfunction = several types of potentiallyreversible changes in the functional state of ECs in response to environmental stimuli. Inducersof endothelial activation are also risk factors for the development of atherosclerosis, indicatingthe significance of EC function in clinical disease processes. Endothelial damage – shear stress,toxic damage, high levels of lipids, viral or bacterial infection.Virtually all the lipids of human plasma are transported as complexes with proteins (=calledlipoproteins). Lipoproteins transport lipids and cholesterol through the bloodstream. Such atransport system is essential to life, but excessive concentrations in plasma of LDL (=low densitylipoprotein) increase the risk of ischemic heart disease.A number of metabolic disorders that involve elevations in plasma concentrations of any of thelipoprotein species are termed hyperlipoproteinemias or hyperlipidemiasTypes of lipoprotein- Chylomicrons- VLDL (very low-density lipoprotein)- IDL (intermediate-density lipoprotein)- LDL (low-density lipoprotein)- HDL (high-density lipoprotein)LDL is strongly implicated in atherosclerosis. At the site of injury to the epithelium,macrophages take up modified LDL. Macrophages filled with LDL (called “foam cells”) migratesub-endothelially giving rise to fatty streaks that lead to atherosclerosis.LDL modification - Oxidation : facilitated by reactive oxygen speciesdecreased by antioxidants present in fruit and vegGlycation – increased in diabetes mellitusOxidised LDL stimulates expression of inflammatory mediators including adhesion molecules formonocytesInfiltration of macrophagesMonocytes bound to endotheliumcross endotheliumtransformed into macrophagesAccumulate large droplets of lipid to become foam cellsLDL uptakeLDL-receptor-mediated endocytosisApolipoprotein B100Negative feedbackBut modified LDL uptake via scavenger receptorNo negative feedbackSmooth muscle proliferationEndothelial cells and macrophages release growth factors esp. PDGFTwo types of smooth muscleResting = contractileProliferating = secretion of extracellular materialsBreakdown of internal elastic laminaPDGF also chemoattractant for medial smooth muscleFibrous cap formed (fragile)Risk factors- Unmodifiable – age, sex, family history- Potentially modifiable - dyslipidaemia, smoking, hypertension, diabetes mellitus,physical activity- Emerging risk factors – Homocysteinaemia, Lipoprotein (a), C-reactive protein,InfectionTreatmentMany of the risk factors are modifiablePlasma lipid reduction using statinsinhibit HMG CoA which reduces intracellular cholesterol synthesisincrease in LDL receptorsreduced plasma cholesterolsuper pill ”Polypill”Stable plaques result in reduced blood flow and stable angina on exertionUnstable plaques can lead to fragile cap ruptures or haemorrhage from plaque. This results in arelease of tissue factor and collagen is exposed causing platelet aggregation, which leads tothrombus formation which reduces lumen diameter and may occlude lumen completely (MI)Non-atheromatous arteriosclerosisArteriolosclerosis occurs in small arteries and arterioles. It involves the thickening of intima andmediaglassy appearance = hyalinefeature of systemic hypertensionMönckeberg’s sclerosismedium sized arteriesmedial calcific sclerosisuncommon idiopathic in elderlycalcified areas, rigid tubes, no narrowing

[Axiom]

AtherosclerosisArteriosclerosis is a thickening and toughening of arterial walls (sclerosis – hardening)It takes 2 major forms- Focal calcification is the deposition of calcium salts following the gradual degenerationof smooth muscle in the tunica media. Typically, this process involves arteries of thelimbs and genital organs. It occurs as part of the aging process and may develop in assocwith atherosclerosis.- Atherosclerosis is the formation of lipid deposits in the tunica media associated withdamage to the endothelial lining.3 stages of development.Endothelial damageUptake of modified LDL, adhesion and infiltration of macrophagesSmooth muscle proliferation and formation of a fibrous capECs can respond to their environment. Endothelial dysfunction = several types of potentiallyreversible changes in the functional state of ECs in response to environmental stimuli. Inducersof endothelial activation are also risk factors for the development of atherosclerosis, indicatingthe significance of EC function in clinical disease processes. Endothelial damage – shear stress,toxic damage, high levels of lipids, viral or bacterial infection.Virtually all the lipids of human plasma are transported as complexes with proteins (=calledlipoproteins). Lipoproteins transport lipids and cholesterol through the bloodstream. Such atransport system is essential to life, but excessive concentrations in plasma of LDL (=low densitylipoprotein) increase the risk of ischemic heart disease.A number of metabolic disorders that involve elevations in plasma concentrations of any of thelipoprotein species are termed hyperlipoproteinemias or hyperlipidemiasTypes of lipoprotein- Chylomicrons- VLDL (very low-density lipoprotein)- IDL (intermediate-density lipoprotein)- LDL (low-density lipoprotein)- HDL (high-density lipoprotein)LDL is strongly implicated in atherosclerosis. At the site of injury to the epithelium,macrophages take up modified LDL. Macrophages filled with LDL (called "foam cells") migratesub-endothelially giving rise to fatty streaks that lead to atherosclerosis.LDL modification - Oxidation : facilitated by reactive oxygen speciesdecreased by antioxidants present in fruit and vegGlycation – increased in diabetes mellitusOxidised LDL stimulates expression of inflammatory mediators including adhesion molecules formonocytesInfiltration of macrophagesMonocytes bound to endotheliumcross endotheliumtransformed into macrophagesAccumulate large droplets of lipid to become foam cellsLDL uptakeLDL-receptor-mediated endocytosisApolipoprotein B100Negative feedbackBut modified LDL uptake via scavenger receptorNo negative feedbackSmooth muscle proliferationEndothelial cells and macrophages release growth factors esp. PDGFTwo types of smooth muscleResting = contractileProliferating = secretion of extracellular materialsBreakdown of internal elastic laminaPDGF also chemoattractant for medial smooth muscleFibrous cap formed (fragile)Risk factors- Unmodifiable – age, sex, family history- Potentially modifiable - dyslipidaemia, smoking, hypertension, diabetes mellitus,physical activity- Emerging risk factors – Homocysteinaemia, Lipoprotein (a), C-reactive protein,InfectionTreatmentMany of the risk factors are modifiablePlasma lipid reduction using statinsinhibit HMG CoA which reduces intracellular cholesterol synthesisincrease in LDL receptorsreduced plasma cholesterolsuper pill "Polypill"Stable plaques result in reduced blood flow and stable angina on exertionUnstable plaques can lead to fragile cap ruptures or haemorrhage from plaque. This results in arelease of tissue factor and collagen is exposed causing platelet aggregation, which leads tothrombus formation which reduces lumen diameter and may occlude lumen completely (MI)Non-atheromatous arteriosclerosisArteriolosclerosis occurs in small arteries and arterioles. It involves the thickening of intima andmediaglassy appearance = hyalinefeature of systemic hypertensionMönckeberg's sclerosismedium sized arteriesmedial calcific sclerosisuncommon idiopathic in elderlycalcified areas, rigid tubes, no narrowing

give a f*ck mayne live fast die young ow

[Guest David Braund]

DUNNO KNOWbetter to crash n burn than fade out motherf*ckerlive life to the fastest...

[SPEAK NO EVIL]

yeah im on the daily kfc but i was on that lecture so thought id share.ayyyeeeeee

[Guest Flat Eric]

yeah im on the daily kfc but i was on that lecture so thought id share.ayyyeeeeee

we dont believe you you need more people

[Bruno Di Gradi]

grilled cheese sandwiches are nice.the george foreman grill is da one 2 make dem on

[Uncle Man]

grilled cheese sandwiches are nice.the george foreman grill is da one 2 make dem on

u know thistuna melt businessnone of this scraping cheese

[Davicious X]

I live my life a quarter pounder at a timeLMAO

[Twirl]

that looks disgusting

[GOLDIE]

yuckbutcheese on apple pie is the bestthem americans..

[Guest David Braund]

DURRTY I TRIED THAT BANANA + HONEY + PEANUT BUTTER S/WICHWAYYYY TO SWEET

amateur

[Fresh]

No indgredient but cheese?Just grate the cheese and fling in on the fire?Put a herb on top and call it a meal?KMT... NO MEAT?phail, any uni student breakfast

[Action Dan]

Fried cheese?WTFllow any friend food.

[Stamina Man]

1/3 lb. Kasseri cheese1 egg1 tbsp. milkFlourOlive oil for pan fryingBrandyLemon juiceCut a slice of Kasseri cheese about 1/3 inch thick. Mix egg with the milk. Dip cheese into the egg mixture, then dip into flour. Fry in a bit of oil in a heavy frying pan on medium heat until golden brown. Then turn. Flame with brandy, if you wish, but be careful. Add a squirt of lemon juice when the flame dies down. Serve with crackers or crusty bread.BOOM BAM

[Fresh]

1/3 lb. Kasseri cheese1 egg1 tbsp. milkFlourOlive oil for pan fryingBrandyLemon juiceCut a slice of Kasseri cheese about 1/3 inch thick. Mix egg with the milk. Dip cheese into the egg mixture, then dip into flour. Fry in a bit of oil in a heavy frying pan on medium heat until golden brown. Then turn. Flame with brandy, if you wish, but be careful. Add a squirt of lemon juice when the flame dies down. Serve with crackers or crusty bread.BOOM BAM

As if the highlighted make a difference.I shall return to this thread with a badboy recipe

[Stamina Man]

1/3 lb. Kasseri cheese1 egg1 tbsp. milkFlourOlive oil for pan fryingBrandyLemon juiceCut a slice of Kasseri cheese about 1/3 inch thick. Mix egg with the milk. Dip cheese into the egg mixture, then dip into flour. Fry in a bit of oil in a heavy frying pan on medium heat until golden brown. Then turn. Flame with brandy, if you wish, but be careful. Add a squirt of lemon juice when the flame dies down. Serve with crackers or crusty bread.BOOM BAM

As if the highlighted make a difference.I shall return to this thread with a badboy recipe

GREEKS DONE THROW ALL THAT sh*t IN LOL, DUNNO WHAT THE DIFFERENCE IS.http://www.recipezaar.com/110939THIS >>>>>>>>>>>>>>

[Fresh]

Cook off ting init, come Stamina...(If you're bad)

[Fresh]

Cook off ting init, come Stamina... Wednesday(If you're bad)

[Stamina Man]

Cook off ting init, come Stamina... Wednesday(If you're bad)